genetic variation in mmp-1 promoter region and

Genetic Variation in MMP-1 Promoter Region and

Analysis of MMP-1 and MMP-9 promoter polymorphisms in early osseointegrated implant failure.

PURPOSE Polymorphisms, such as a guanine inserted at position -1607 in the promoter region of human matrix metalloprotenase 1 (MMP-1) or a C-1562T substitution in the MMP-9 gene, have been shown to increase the transcriptional activity of these MMPs. The objective of this study was to investigate the possible relationship between these polymorphisms and early implant failure. MATERIALS AND ME...

Prognostic significance of MMP-1 and MMP-3 functional promoter polymorphisms in colorectal cancer.

PURPOSE Matrix metalloproteinase (MMP) belongs to a large group of proteases capable of breaking essentially all components of the extracellular matrix. They are implicated in all steps of tumorogenesis, cancer invasion, and metastasis. Among them, metalloproteinase type 1 (MMP-1) is implicated in tumor invasion and metastasis in different types of cancers including colorectal cancer in which i...

the study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region

چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...

Genetic Variation in the Growth Hormone Promoter Region of Anas platyrhynchos, a Duck Native to Myanmar

Genetic variations were detected in duck growth hormone (GH) gene promoters at 8 positions in the genome of ducks from 3 regions (Mandalay, Khayan, and Sittwe) in Myanmar. Different frequencies were detected in the 3 regions. Higher frequencies were detected at positions, 244, 294, 586, and 665 of the GH promoter from both Mandalay and Khayan than in the ducks from Sittwe. The duck populations ...

MMP-1 promoter polymorphism in Korean with generalized aggressive periodontitis

Purpose: The aim of this study was to investigate matrix metalloproteinase 1 (MMP-1) gene polymorphism (1G/2G at -1607 and A/G at -519) in Korean subject and to assess the association between polymorphism and periodontal status. Methods: Forty nine generalized aggressive periodontitis (GAP) patients and 57 periodontally healthy children were recruited and genomic DNA was extracted from buccal s...